Imatinib for bleomycin induced pulmonary toxicity: a case report and evidence‐base review
نویسندگان
چکیده
The evidence supporting therapy with imatinib for bleomycin-induced pneumonitis (BIP) is equivocal. Further experience is needed to establish its role in BIP management. While it may be considered in the management of BIP, it is important to be mindful of the adverse effects including thrombocytopenia and gastrointestinal bleeding.
منابع مشابه
P-174: Good Pregnancy Outcome after Prenatal Exposure to Bleomycin, Etoposide and Cisplatin for Ovarian Immature Teratoma: A Case Report and Literature Review
Background: The administration of bleomycin plus etoposide and cisplatin during pregnancy is rare. Materials and Methods: We describe a case with good pregnancy outcome after exposure to these chemotherapeutic agents at the third trimester of pregnancy. Results: Pregnant woman with stage IIIc immature teratoma underwent surgical staging, and received two cycles of bleomycin, etoposide and cispl...
متن کاملTyrosine kinase inhibitors in the treatment of systemic sclerosis: from animal models to clinical trials.
Efficient antifibrotic therapies are not available for patients with systemic sclerosis (SSc). This review summarizes the current preclinical and clinical evidence for imatinib and related tyrosine kinase inhibitors as potential antifibrotic therapies for SSc and other fibrotic diseases. In experimental models of SSc, imatinib, nilotinib, and dasatinib demonstrated strong antifibrotic effects. ...
متن کاملEffect of nilotinib on bleomycin-induced acute lung injury and pulmonary fibrosis in mice.
BACKGROUND The tyrosine kinase inhibitor imatinib mesylate was developed as an inhibitor of the kinase activity of BCR-ABL. However, imatinib also has potent inhibitory activity against the platelet-derived growth factor receptor (PDGFR). Nilotinib is approved for treating patients with chronic myeloid leukemia showing resistance or intolerance to imatinib. Like imatinib, nilotinib selectively ...
متن کاملEarly and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study
Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods: This study was carried out using 52 rats. Pulmona...
متن کاملBeneficial effects of N-acetylcysteine on protease-antiprotease balance in attenuating bleomycin-induced pulmonary fibrosis in rats
Objective(s): The role of N-acetylcysteine (NAC) as an anti-oxidant in attenuating bleomycin-induced pulmonary fibrosis has been reported. However, its effect on parenchymal remodeling via regulating the protease-antiprotease balance is not fully defined. Therefore, the present study was designed to explore the possible role of matrix metalloproteinases (MMP), tissue i...
متن کامل